SiDeS on Yeast

The following table lists the 73 sets of S. Cerevisiae proteins that induce significantly dense subgraphs in the yeast PPI network obtained from BIND and DIP , which are identified by SiDeS.

The dense subgraphs are sorted according to their p-value, which is defined as the probability of existence of such a large set of proteins that would induce such a dense subgraph in the network, according to a reference graph model.

For each dense subgraph, the most significant 10 GO terms that are found to be significantly enriched in the corresponding set of proteins, as identified by the Ontologizer, are also listed. For each annotation, if there are P proteins in the subgraph, C of which are attached to the corresponding term, and the term is attached to T proteins in total, then sensitivity is defined as C/T, whereas specificity is defined as P/T. The reported p-value for the annotation is the one assigned by the Ontologizer.


RankSize (#Prot, #Int)p-valueProteins

122, 1452e-234SPT7 TAF90 TSM1 TAF61 TAF10 NGG1 ADR1 SPT3 ADA2 GCN4 TBP1 TAF6 GCN5 TAF1 TRA1 SPT8 TAF19 TAF40 TAF4 TAF17 ADA5 HFI1
AnnotationSpecificity(%)Sensitivity(%)p-value
[F] transcription regulator activity90.96.94e-20
[C] transcription factor complex90.917.16e-20
[C] membrane-enclosed lumen90.93.31e-13
[P] protein amino acid acylation63.632.61e-11
[C] organelle lumen90.93.32e-10
[P] histone modification63.624.61e-09
[C] nuclear lumen90.94.61e-08
[P] G1-specific transcription in mitotic cell cycle40.969.22e-08
[C] transcription factor TFIID complex50.078.62e-07
[C] protein complex90.91.62e-07

221, 1233e-181LSM2 DHH1 LSM8 PAT1 LSM8 LSM6 EDC3 LSM4 LSM5 KEM1 PAT1 PRP31 LSM1 SNU114 SMD2 LSM3 PRP24 LSM7 DCP2 DCP1 PRP4
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] cytoplasmic mRNA processing body36.8100.01e-14
[C] small nuclear ribonucleoprotein complex63.218.82e-14
[C] spliceosome complex52.613.51e-09
[P] RNA metabolism94.74.32e-09
[C] protein complex100.01.57e-09
[C] ribonucleoprotein complex68.43.87e-08
[P] RNA catabolism63.220.34e-07
[F] binding84.21.85e-07
[C] snRNP U642.1100.02e-05
[P] mRNA metabolism94.710.22e-05

320, 1141e-169DBP10 YDR060W NUG1 NSA2 NSA1 NOP7 CIC1 SSF1 RPF1 CKA1 YKR081C ERB1 HAS1 NOP2 BRX1 DNL4 YTM1 NOP4 TIF6 MAK5
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] cytoplasm organization and biogenesis90.08.43e-12
[P] ribosome biogenesis and assembly90.08.44e-10
[C] nucleolus80.07.71e-09
[C] membrane-enclosed lumen80.02.67e-09
[C] organelle lumen80.02.65e-07
[C] nuclear lumen80.03.71e-05
[C] non-membrane-bound organelle80.02.03e-05
[C] intracellular non-membrane-bound organelle80.02.03e-05
[P] cell organization and biogenesis95.01.45e-05
[C] nucleus95.01.22e-04

420, 1124e-163REF2 PCF11 CFT1 GLC7 RNA15 PTI1 FIP1 RSM7 MPE1 PAP1 CFT2 YSH1 RNA14 PFS2 SSU72 CLP1 YTH1 HCA4 SWD2 PTA1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] mRNA cleavage factor complex90.094.78e-36
[P] RNA 3'-end processing80.069.62e-16
[C] membrane-enclosed lumen100.03.31e-15
[C] organelle lumen100.03.32e-12
[P] mRNA 3'-end processing75.071.41e-11
[P] mRNA cleavage65.086.77e-11
[P] transcription termination40.050.02e-10
[P] RNA metabolism95.04.67e-10
[P] transcription termination from RNA polymerase II promoter40.057.11e-09
[C] nuclear lumen95.04.47e-09

518, 945e-138PRE7 PPH22 RPN5 PRE4 PRE1 PUP3 SCL1 PRE9 PUP2 RPN10 PRE3 PRE8 PRE5 PRE6 PUP1 RPN8 PRE10 PRE2
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] proteasome complex (sensu Eukaryota)94.439.55e-32
[P] cellular catabolism94.45.56e-13
[P] catabolism94.45.37e-13
[P] protein catabolism94.411.82e-12
[P] cellular protein catabolism94.412.63e-12
[P] macromolecule catabolism94.46.74e-12
[P] biopolymer catabolism94.47.75e-11
[P] proteolysis94.411.03e-10
[F] peptidase activity83.315.51e-09
[C] protein complex100.01.42e-08

612, 622e-134CDC27 DOC1 APC11 APC4 CDC26 DOC1 CDC23 CDC16 APC9 APC2 APC1 APC5
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] ubiquitin ligase complex100.031.47e-22
[C] nuclear ubiquitin ligase complex100.047.82e-20
[P] chromosome segregation100.010.77e-16
[P] cyclin catabolism100.091.72e-14
[F] ligase activity90.99.98e-11
[P] mitotic metaphase/anaphase transition100.073.31e-10
[P] cell cycle100.02.92e-09
[P] cellular catabolism100.03.69e-09
[P] catabolism100.03.51e-08
[P] regulation of biological process100.01.92e-08

717, 822e-114ROX3 MED8 MED22 MED2 SRB4 SRB5 MED20 MED6 MED14 SIN4 MED9 MED7 GAL11 MED4 GAL4 SRB10 MED1
AnnotationSpecificity(%)Sensitivity(%)p-value
[F] transcription regulator activity100.05.95e-19
[C] DNA-directed RNA polymerase II, holoenzyme88.220.01e-16
[C] membrane-enclosed lumen94.12.62e-11
[C] mediator complex88.275.06e-10
[C] organelle lumen94.12.67e-09
[C] nuclear lumen94.13.72e-07
[F] RNA polymerase II transcription mediator activity88.275.04e-07
[C] protein complex94.11.32e-06
[P] transcription100.03.83e-06
[C] nucleus100.01.15e-05

815, 646e-85MUD1 LUC7 SNU56 PRP3 SNU71 SMD1 NAM8 SNP1 PRP42 PRP40 SMD3 PRP39 STO1 SAE1 YHC1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] spliceosome complex93.318.91e-17
[C] small nuclear ribonucleoprotein complex86.720.33e-16
[C] commitment complex60.081.88e-16
[C] ribonucleoprotein complex100.04.41e-14
[F] binding100.01.72e-09
[P] RNA metabolism100.03.65e-08
[C] protein complex100.01.24e-07
[C] snRNP U180.070.61e-06
[P] mRNA processing100.011.81e-05
[P] RNA splicing100.013.01e-05

914, 555e-69RRP42 RRP45 RRP43 MTR3 SKI6 RRP4 LRP1 MAS1 RRP40 DIS3 RRP6 SKI7 CSL4 RRP46
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] exosome (RNase complex)92.9100.04e-34
[C] nuclear exosome (RNase complex)85.7100.02e-27
[C] cytoplasmic exosome (RNase complex)71.4100.03e-23
[P] RNA catabolism92.922.02e-12
[P] cellular catabolism92.94.22e-09
[P] catabolism92.94.13e-09
[P] macromolecule catabolism92.95.11e-08
[P] biopolymer catabolism92.95.97e-08
[P] cytoplasm organization and biogenesis85.75.62e-07
[P] mRNA catabolism92.925.52e-06

1010, 381e-66OST4 OST2 WBP1 OST5 STT3 OST2 OST5 OST1 SWP1 OST3
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] oligosaccharyl transferase complex100.088.92e-18
[P] glycoprotein metabolism100.015.19e-09
[C] endoplasmic reticulum100.03.13e-08
[F] oligosaccharyl transferase activity100.088.93e-07
[P] biopolymer glycosylation100.016.76e-07
[P] protein amino acid glycosylation100.016.72e-06
[F] transferase activity, transferring glycosyl groups100.010.86e-06
[P] glycoprotein biosynthesis100.015.48e-06
[C] organelle membrane100.01.81e-05
[C] endoplasmic reticulum membrane100.07.93e-05

1113, 485e-59APG12 RPN6 RPN11 RPN12 RPN9 RAD23 RPN3 RPN1 RPT1 RPT4 ECM29 18 UBP6
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] proteasome complex (sensu Eukaryota)84.625.61e-20
[C] proteasome regulatory particle (sensu Eukaryota)69.242.98e-14
[C] proteasome regulatory particle, lid subcomplex (sensu Eukaryota)38.555.62e-07
[P] catabolism76.93.11e-06
[P] protein catabolism76.96.92e-06
[P] macromolecule catabolism76.93.93e-06
[P] biopolymer catabolism76.94.51e-05
[P] cellular catabolism69.22.93e-05
[P] cellular protein catabolism69.26.79e-05
[P] proteolysis69.25.82e-04

1213, 485e-59TRS20 GSG1 TRS23 TRS120 TRS31 TRS65 GYP6 BET3 BET5 3 TRS130 ALF1 TRS33
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] TRAPP complex76.9100.03e-23
[C] Golgi cis-face76.976.92e-11
[C] Golgi apparatus76.96.84e-11
[P] transport84.61.44e-05
[P] localization84.61.37e-05
[P] cellular localization84.62.39e-05
[P] Golgi vesicle transport76.97.62e-04
[P] secretory pathway76.95.43e-04
[P] secretion76.95.23e-04
[P] ER to Golgi vesicle-mediated transport76.915.21e-03

1310, 357e-54ARF1 RET1 RET2 SEC26 GLO3 SEC28 BET1 BOS1 SEC22 SEC21
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] Golgi apparatus80.05.43e-08
[C] cytoplasmic vesicle70.08.05e-08
[C] vesicle70.08.02e-07
[C] cytoplasmic membrane-bound vesicle70.08.03e-07
[C] membrane coat50.015.23e-06
[P] Golgi vesicle transport90.06.92e-04
[P] secretory pathway90.04.82e-04
[P] secretion90.04.72e-04
[C] coated membrane50.015.24e-04
[P] transport90.01.21e-03

1412, 421e-51VMA2 RAV2 TFP1 RAV1 SKP1 VMA8 VMA7 VMA10 VMA5 STV1 VPH1 VMA4
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] cell homeostasis100.013.27e-18
[P] homeostasis100.012.51e-17
[C] hydrogen-translocating V-type ATPase complex75.064.32e-15
[P] vacuolar transport100.019.72e-09
[C] vacuole75.06.18e-09
[F] ATPase activity, coupled to movement of substances75.020.94e-07
[F] cation-transporting ATPase activity75.056.28e-07
[F] transporter activity75.03.08e-07
[P] transport100.01.52e-06
[P] regulation of pH100.050.02e-06

159, 308e-49GCD6 GCD2 SUI3 FKH1 SUI2 GCN3 GCD7 GCD1 IST1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] eukaryotic translation initiation factor 2B complex55.6100.02e-12
[F] translation regulator activity77.815.23e-11
[C] multi-eIF complex44.440.03e-07
[F] translation factor activity, nucleic acid binding77.820.09e-06
[C] ribosome66.73.39e-05
[F] enzyme regulator activity55.63.16e-04
[F] binding88.90.92e-03
[P] macromolecule biosynthesis88.92.02e-03
[C] ribonucleoprotein complex66.71.74e-03
[C] eukaryotic translation initiation factor 2 complex22.266.77e-03

1610, 324e-42NOT4 NOT1 DBF2 CAF130 NOT3 CAF40 POP2 CAF4 NOT5 CCR4
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] CCR4-NOT complex90.075.03e-09
[C] transcription factor complex90.07.74e-08
[P] regulation of RNA metabolism60.027.34e-06
[P] regulation of biological process90.01.61e-05
[C] membrane-enclosed lumen90.01.52e-05
[P] regulation of cellular metabolism90.02.43e-05
[P] regulation of metabolism90.02.35e-05
[P] regulation of cellular process90.01.66e-05
[P] regulation of cellular physiological process90.01.66e-05
[P] regulation of physiological process90.01.67e-05

1711, 333e-33SLA1 ABP1 RVS167 YSC84 BZZ1 MYO3 MYO5 APP1 BEE1 BSP1 BBC1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] cell cortex100.011.68e-15
[C] cytoskeleton100.05.84e-13
[C] non-membrane-bound organelle100.01.43e-05
[C] intracellular non-membrane-bound organelle100.01.43e-05
[C] cortical cytoskeleton90.919.23e-04
[P] cytoskeleton organization and biogenesis72.74.03e-04
[P] response to osmotic stress45.510.65e-04
[P] cell division45.54.41e-03
[P] development54.52.22e-03
[P] cell organization and biogenesis100.00.83e-03

189, 262e-32CWC2 SYF1 PRP45 ISY1 YJU2 PRP19 CEF1 PRP46 SNT309
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] spliceosome complex77.89.54e-07
[C] ribonucleoprotein complex77.82.01e-04
[P] RNA metabolism88.91.98e-03
[P] mRNA processing88.96.32e-02
[P] RNA splicing88.97.02e-02
[C] nucleus100.00.64e-02
[P] mRNA metabolism88.94.57e-02
[P] nucleobase, nucleoside, nucleotide and nucleic acid metabolism100.00.71e-01
[C] protein complex77.80.62e-01
[F] RNA splicing factor activity, transesterification mechanism44.48.02e-01

1910, 294e-31ATP5 ATP17 ATP1 ATP11 ATP18 ATP6 ATP7 ATP2 ATP4 ATP20
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] proton-transporting ATP synthase complex90.056.23e-20
[C] proton-transporting two-sector ATPase complex90.056.23e-17
[P] hydrogen transport90.050.02e-14
[C] proton-transporting ATP synthase complex, coupling factor F(o)70.070.05e-13
[P] cofactor metabolism90.07.61e-10
[P] nucleotide metabolism90.011.12e-09
[P] phosphorus metabolism90.05.15e-09
[P] nucleotide biosynthesis90.017.38e-09
[P] cofactor biosynthesis90.016.41e-08
[P] generation of precursor metabolites and energy90.04.61e-08

208, 222e-29YBR175W YDR469W RAD6 SET1 BRE2 YPL138C SHG1 YAR003W
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] histone methyltransferase complex87.587.57e-15
[P] protein amino acid alkylation87.536.82e-07
[C] COMPASS complex87.587.59e-07
[C] chromatin remodeling complex87.510.11e-06
[P] biopolymer methylation87.521.26e-06
[C] chromosome87.52.68e-06
[P] histone modification100.014.02e-05
[F] transferase activity, transferring one-carbon groups87.510.94e-05
[P] gene silencing75.07.72e-04
[F] protein methyltransferase activity87.550.08e-04

2110, 274e-24RPO21 RPB1 RPB7 RPB9 TFG2 TFG1 RPB3 RPB11 RPB2 ANC1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] DNA-directed RNA polymerase II, holoenzyme100.012.04e-10
[C] RNA polymerase complex66.718.82e-09
[C] membrane-enclosed lumen100.01.51e-06
[C] organelle lumen100.01.54e-05
[C] nuclear lumen100.02.13e-04
[C] protein complex100.00.71e-03
[P] transcription100.02.09e-03
[C] transcription factor TFIIF complex33.3100.01e-02
[C] DNA-directed RNA polymerase II, core complex66.746.21e-02
[F] nucleotidyltransferase activity66.78.73e-02

227, 171e-21POL12 RFC5 POL30 ECO1 RFC2 RFC3 RFC4
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] chromosome100.02.68e-07
[C] DNA replication factor C complex57.140.03e-06
[P] chromosome segregation71.44.94e-05
[F] DNA clamp loader activity57.157.15e-05
[P] response to stimulus85.71.21e-03
[P] DNA replication100.06.93e-03
[C] replication fork85.715.44e-03
[C] non-membrane-bound organelle100.00.98e-03
[C] intracellular non-membrane-bound organelle100.00.98e-03
[P] DNA metabolism100.01.68e-03

238, 202e-21VAM6 VPS41 MON1 PEP3 VPS33 PEP5 VPS16 VPS8
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] HOPS complex75.0100.08e-14
[C] vacuole87.54.81e-08
[P] vacuole organization and biogenesis75.017.61e-07
[P] membrane organization and biogenesis75.07.28e-05
[C] organelle membrane87.51.61e-04
[C] vacuolar membrane87.58.52e-04
[P] endosome transport62.513.25e-04
[C] membrane87.50.97e-03
[P] transport87.50.91e-02
[P] vacuolar transport62.58.22e-02

249, 233e-21TOM20 YHR003C TIM17 TOM40 TOM22 TOM70 TOM7 TOM6 TOM5
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] mitochondrial outer membrane translocase complex77.8100.02e-15
[C] envelope100.03.01e-09
[C] organelle envelope100.03.08e-08
[F] transporter activity88.92.72e-07
[C] outer membrane88.913.82e-07
[C] organelle membrane100.02.02e-06
[C] organelle outer membrane88.913.84e-06
[F] protein transporter activity88.915.72e-05
[C] membrane100.01.13e-05
[C] mitochondrion100.01.24e-05

259, 221e-17BRE1 SMC1 SMC2 SPC19 YEL043W TID3 SMC3 SPC24 NUF2
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] chromosome segregation66.75.82e-06
[C] chromosome77.82.65e-05
[C] Ndc80 complex33.375.07e-05
[C] nuclear chromosome77.83.11e-03
[C] condensed chromosome77.89.22e-02
[C] condensed nuclear chromosome77.810.32e-02
[C] cohesin complex22.240.04e-02
[C] kinetochore44.47.87e-02
[F] structural constituent of cytoskeleton44.48.32e-01
[F] structural molecule activity44.41.62e-01

269, 221e-17MRS5 TIM22 TIM9 TIM13 TIM10 TIM54 TIM23 TIM18 TIM8
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] envelope100.03.01e-09
[F] transporter activity100.03.01e-09
[C] mitochondrial inner membrane protein insertion complex44.4100.05e-08
[C] mitochondrial intermembrane space protein transporter complex44.4100.06e-08
[C] organelle envelope100.03.08e-08
[P] mitochondrion organization and biogenesis77.89.21e-06
[P] mitochondrial membrane organization and biogenesis77.843.83e-06
[F] protein transporter activity100.017.64e-06
[P] membrane organization and biogenesis77.88.44e-06
[P] protein import into mitochondrial inner membrane77.877.86e-06

278, 191e-17GCS1 YPT1 YPT31 YIP5 YIP1 YHR105W PEP12 YIP4
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] transport87.50.93e-03
[C] Golgi apparatus50.02.74e-03
[P] localization87.50.84e-03
[C] endosome37.54.81e-02
[P] vesicle-mediated transport87.52.65e-02
[F] enzyme binding25.025.01e-01
[C] ER-Golgi intermediate compartment12.550.05e-01
[P] actin filament reorganization during cell cycle12.533.37e-01

288, 191e-17GBP2 SUB2 HPR1 THO1 THP2 MFT1 RLR1 RLR1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] transcription export complex71.471.41e-10
[C] THO complex57.1100.06e-09
[P] establishment of RNA localization85.78.55e-05
[P] nucleobase, nucleoside, nucleotide and nucleic acid transport85.78.09e-05
[P] RNA localization85.77.31e-04
[P] RNA elongation from RNA polymerase II promoter57.117.46e-03
[P] nuclear transport85.75.91e-02
[P] nucleocytoplasmic transport85.75.62e-02
[P] RNA elongation57.115.42e-02
[F] binding85.70.75e-02

297, 162e-17SEC17 SLY1 TLG1 VPS45 YKT6 VTI1 TLG2
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] Golgi apparatus71.43.46e-05
[F] intracellular transporter activity71.417.26e-04
[P] membrane organization and biogenesis71.46.01e-03
[F] transporter activity71.41.72e-03
[P] transport100.00.92e-03
[P] localization100.00.84e-03
[P] vacuole organization and biogenesis42.98.84e-03
[C] organelle subcompartment28.615.43e-02
[P] vesicle-mediated transport100.02.65e-02
[P] cell organization and biogenesis100.00.51e-01

306, 131e-16ELP2 IKI1 KTI12 ELP6 ELP4 ELP3
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] transcription elongation factor complex83.320.84e-07
[F] transcriptional elongation regulator activity83.322.78e-05
[F] transcription regulator activity83.31.73e-04
[C] membrane-enclosed lumen100.01.03e-04
[C] organelle lumen100.01.03e-03
[P] regulation of cellular metabolism83.31.33e-03
[P] regulation of cellular process83.30.94e-03
[P] regulation of cellular physiological process83.30.95e-03
[P] regulation of biological process83.30.91e-02
[C] nuclear lumen100.01.41e-02

317, 153e-13EXO84 SEC5 SEC3 SEC15 SEC6 SEC10 SEC8
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] exocyst100.087.54e-16
[C] cell cortex100.07.45e-09
[C] bud85.75.03e-07
[P] cell division85.75.34e-07
[C] site of polarized growth85.74.65e-07
[P] membrane organization and biogenesis85.77.22e-06
[P] vesicle docking85.742.93e-06
[P] reproduction85.72.78e-06
[P] exocytosis100.020.01e-05
[C] incipient bud site57.111.41e-05

327, 153e-13BEM1 BOI2 CDC24 RSR1 STE20 BEM4 CDC24
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] development100.02.27e-06
[C] site of polarized growth83.33.83e-05
[P] cellular morphogenesis100.04.31e-04
[P] cell communication83.32.92e-04
[C] incipient bud site50.08.64e-04
[C] bud66.73.31e-03
[C] cell projection50.07.13e-03
[P] reproduction66.71.81e-02
[P] interaction between organisms50.03.03e-02
[P] cell division50.02.78e-02

337, 153e-13FUS3 STE50 STE5 GPA1 STE11 STE4 STE11
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] interaction between organisms100.05.91e-08
[P] regulation of conjugation100.027.31e-07
[P] reproductive physiological process100.03.78e-07
[P] reproductive cellular physiological process100.03.79e-07
[P] cell communication100.03.51e-06
[P] reproduction100.02.72e-06
[P] growth83.34.84e-06
[P] response to stimulus100.01.22e-04
[C] heterotrimeric G-protein complex33.366.74e-04
[P] regulation of biological process100.01.05e-04

346, 124e-12TSC11 TOR2 AVO2 LST8 AVO1 TOR2
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] TORC 2 complex100.062.51e-12
[P] cell growth100.041.72e-11
[P] regulation of cell growth100.045.51e-07
[P] regulation of growth100.038.52e-07
[P] growth100.04.88e-07
[P] establishment and/or maintenance of cytoskeleton polarity100.062.52e-06
[P] establishment and/or maintenance of actin cytoskeleton polarity100.062.59e-05
[P] development100.01.81e-04
[C] extrinsic to internal side of plasma membrane40.050.09e-04
[P] cellular morphogenesis100.03.51e-03

356, 124e-12GIC2 GIC1 CDC42 ZDS2 CLA4 RGA1
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] development100.02.21e-05
[P] cell division83.34.43e-05
[P] cellular morphogenesis100.04.32e-04
[P] cell communication83.32.93e-04
[P] reproduction83.32.23e-04
[P] regulation of biological process100.01.09e-04
[P] regulation of cellular process100.01.13e-03
[P] regulation of cellular physiological process100.01.13e-03
[P] regulation of physiological process100.01.13e-03
[C] cell projection50.07.14e-03

368, 172e-10RPB5 RPA12 RPC25 RPC34 RPB10 RPB8 RPA190 RPO26
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] RNA polymerase complex100.025.04e-16
[C] membrane-enclosed lumen100.01.35e-06
[C] DNA-directed RNA polymerase I complex75.042.92e-05
[C] DNA-directed RNA polymerase III complex75.035.33e-05
[P] transcription from RNA polymerase I promoter75.022.25e-05
[C] organelle lumen100.01.39e-05
[P] transcription from RNA polymerase III promoter75.016.24e-04
[C] nuclear lumen100.01.85e-04
[F] nucleotidyltransferase activity100.011.68e-04
[C] protein complex100.00.62e-03

375, 93e-10DAD1 DAM1 DAM1 DUO1 SPC34
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] regulation of cell organization and biogenesis100.021.16e-07
[C] microtubule associated complex100.012.91e-05
[C] cytoskeleton100.02.14e-04
[F] structural molecule activity100.01.66e-04
[C] kinetochore100.07.89e-04
[C] chromosome100.01.51e-03
[C] DASH complex100.057.14e-03
[C] spindle100.05.25e-03
[P] cell cycle100.01.17e-03
[P] microtubule polymerization or depolymerization100.036.42e-02

387, 142e-09HTB2 REB1 ISW1 MOT1 VPS1 NPL6 NHP6B
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] chromosome71.41.94e-03
[C] nuclear chromosome71.42.24e-02
[F] transcription termination factor activity14.3100.05e-01

397, 142e-09RPG1 ARC40 TIF35 HCR1 NIP1 TIF5 TFIIB
AnnotationSpecificity(%)Sensitivity(%)p-value
[F] translation regulator activity71.410.92e-07
[C] eukaryotic 43S preinitiation complex71.411.43e-07
[C] eukaryotic translation initiation factor 3 complex57.157.15e-07
[F] translation factor activity, nucleic acid binding71.414.33e-04
[C] multi-eIF complex28.620.01e-02
[P] macromolecule biosynthesis71.41.24e-02
[C] protein complex85.70.53e-01
[F] binding71.40.65e-01
[P] cellular biosynthesis71.40.85e-01
[P] biosynthesis71.40.77e-01

407, 142e-09NUP84 PSE1 SEH1 NUP145 NUP57 NUP120 NUP85
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] nuclear pore85.712.22e-07
[P] nuclear organization and biogenesis85.712.81e-06
[P] establishment of RNA localization100.09.93e-06
[P] nucleobase, nucleoside, nucleotide and nucleic acid transport100.09.35e-06
[C] nuclear envelope85.76.56e-06
[P] RNA localization100.08.56e-06
[F] structural molecule activity85.72.32e-05
[C] envelope85.72.05e-05
[P] chromosome localization42.975.06e-04
[C] organelle envelope85.72.08e-04

417, 142e-09ACTIN PEA2 FUS1 BNR1 BUD6 FUS2 BNI1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] site of polarized growth85.74.61e-07
[P] reproduction85.72.72e-06
[P] development85.72.27e-06
[P] regulation of cell organization and biogenesis57.121.12e-05
[C] polarisome42.960.05e-05
[P] cellular morphogenesis85.74.31e-04
[P] response to stimulus85.71.22e-04
[P] interaction between organisms57.14.04e-04
[C] cell cortex57.14.29e-04
[P] cell division57.13.52e-03

427, 142e-09SEC31 EMP24 SEC24 SEC13 ERV25 ERP2 ERP1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] cytoplasmic vesicle100.08.04e-10
[C] vesicle100.08.01e-09
[C] cytoplasmic membrane-bound vesicle100.08.02e-09
[C] Golgi apparatus100.04.82e-08
[P] transport100.00.92e-03
[P] Golgi vesicle transport100.05.33e-03
[P] localization100.00.84e-03
[P] secretory pathway100.03.84e-03
[P] secretion100.03.74e-03
[C] membrane coat42.99.16e-03

436, 117e-08ENP1 PWP2 NOP1 CBF5 SIK1 YMR093W
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] membrane-enclosed lumen100.01.05e-04
[P] cytoplasm organization and biogenesis100.02.89e-04
[C] ribonucleoprotein complex83.31.53e-03
[C] organelle lumen100.01.05e-03
[C] nucleolus100.02.96e-03
[C] small nucleolar ribonucleoprotein complex83.39.17e-03
[P] ribosome biogenesis and assembly100.02.81e-02
[C] nuclear lumen100.01.42e-02
[P] RNA metabolism100.01.42e-02
[C] non-membrane-bound organelle100.00.82e-02

446, 117e-08CNS1 RVB1 PGK1 HSC82 UBP10 SSA1
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] protein folding50.04.53e-01
[F] unfolded protein binding50.05.74e-01
[F] phosphoglycerate kinase activity16.7100.01e-00

456, 117e-08NUP42 MSN5 PAB1 NUP49 NUP133 NUP2
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] nuclear organization and biogenesis66.78.59e-04
[C] nuclear pore66.78.21e-03
[C] nuclear envelope66.74.31e-02
[P] protein export from nucleus83.311.62e-02
[F] structural molecule activity66.71.62e-02
[P] establishment of RNA localization66.75.64e-02
[C] envelope66.71.34e-02
[P] nucleobase, nucleoside, nucleotide and nucleic acid transport66.75.36e-02
[P] RNA localization66.74.96e-02
[P] nuclear transport83.34.98e-02

467, 139e-06SSZ1 AHA1 PPT1 TDH3 SSA2 YPT6 SSE1
AnnotationSpecificity(%)Sensitivity(%)p-value
[F] unfolded protein binding42.95.73e-01
[P] protein folding42.94.56e-01
[F] nucleotide binding28.65.76e-01
[C] external encapsulating structure28.62.89e-01

477, 139e-06FYV14 YDR449C KRR1 YGR090W ENP2 UTP20 KRE33
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] membrane-enclosed lumen85.71.03e-04
[C] organelle lumen85.71.03e-03
[C] nucleolus85.72.93e-03
[P] cytoplasm organization and biogenesis71.42.34e-03
[C] nuclear lumen85.71.49e-03
[C] non-membrane-bound organelle85.70.81e-02
[C] intracellular non-membrane-bound organelle85.70.81e-02
[P] ribosome biogenesis and assembly71.42.33e-02
[C] ribonucleoprotein complex57.11.24e-02
[P] RNA metabolism71.41.24e-02

487, 139e-06PRP11 PRP9 SMB1 PRP21 YNR053C SNU66 SMX2
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] small nuclear ribonucleoprotein complex85.79.49e-07
[C] spliceosome complex71.46.82e-04
[C] ribonucleoprotein complex85.71.73e-04
[P] RNA metabolism85.71.42e-02
[F] binding85.70.73e-02
[P] mRNA processing85.74.72e-01
[P] RNA splicing85.75.22e-01
[C] nucleus100.00.42e-01
[C] protein complex85.70.52e-01
[P] mRNA metabolism85.73.44e-01

497, 139e-06QCR7 RIP1 COB QCR9 QCR8 CYT1 UBIQUINOL-CYTOCHROME
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] respiratory chain complex III85.766.71e-15
[C] ubiquinol-cytochrome-c reductase complex85.766.79e-13
[P] electron transport85.723.12e-08
[C] envelope85.72.05e-06
[F] oxidoreductase activity, acting on diphenols and related substances as donors71.462.57e-06
[P] phosphorus metabolism85.73.48e-06
[P] generation of precursor metabolites and energy85.73.11e-05
[C] organelle envelope85.72.08e-05
[P] oxidative phosphorylation85.715.82e-04
[F] oxidoreductase activity85.73.03e-04

505, 82e-05MNN10 MNN11 ANP1 HOC1 MNN9
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] mannosyltransferase complex100.083.31e-11
[C] organelle subcompartment100.038.55e-11
[C] Golgi apparatus100.03.47e-06
[P] glycoprotein metabolism100.09.45e-05
[C] Golgi stack100.038.51e-04
[F] transferase activity, transferring glycosyl groups100.06.83e-03
[P] glycoprotein biosynthesis100.09.64e-03
[P] biopolymer glycosylation80.08.38e-03
[P] macromolecule biosynthesis100.01.22e-02
[F] alpha-1,6-mannosyltransferase activity80.080.05e-02

516, 107e-04SEC35 COG2 SEC34 SED5 YPR105C MTW1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] Golgi transport complex60.037.58e-05
[C] Golgi apparatus80.02.78e-04
[P] intra-Golgi vesicle-mediated transport80.019.08e-03
[P] Golgi vesicle transport80.03.12e-01
[P] secretory pathway80.02.22e-01
[P] secretion80.02.12e-01
[C] cell fraction40.02.33e-01
[P] cellular localization80.00.85e-01
[P] transport80.00.56e-01
[P] retrograde transport, vesicle recycling within Golgi60.075.07e-01

526, 107e-04MCM7 MCM3 MCM2 CDC45 CDC46 GLT1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] pre-replicative complex83.335.75e-08
[C] MCM complex66.766.72e-07
[F] chromatin binding66.719.01e-04
[C] chromosome83.31.91e-03
[F] helicase activity66.75.33e-03
[C] replication fork83.312.86e-03
[P] pre-replicative complex formation and maintenance83.338.57e-03
[C] replication fork (sensu Eukaryota)66.718.23e-02
[C] membrane-enclosed lumen83.30.83e-02
[C] protein complex100.00.56e-02

536, 107e-04IML3 AME1 MCM21 CBF2 OKP1 CTF19
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] chromosome segregation100.05.84e-08
[C] kinetochore100.011.84e-06
[C] chromosome100.02.39e-06
[C] microtubule associated complex66.712.99e-05
[C] cytoskeleton83.32.61e-04
[C] nuclear chromosome100.02.65e-04
[C] COMA complex66.7100.03e-03
[C] chromosome, pericentric region100.010.95e-03
[C] non-membrane-bound organelle100.00.82e-02
[C] intracellular non-membrane-bound organelle100.00.82e-02

546, 107e-04VPS25 VPS37 VPS36 VPS20 VPS28 VPS22
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] endosome100.09.72e-09
[C] endosome membrane100.042.92e-08
[C] ESCRT II complex50.0100.06e-06
[P] ubiquitin-dependent protein catabolism via the multivesicular body pathway100.040.01e-04
[P] response to extracellular stimulus50.016.72e-04
[P] regulation of transcription by carbon catabolites50.060.03e-04
[P] cellular catabolism100.01.94e-04
[P] catabolism100.01.94e-04
[P] protein catabolism100.04.27e-04
[P] macromolecule catabolism100.02.48e-04

554, 51e-01RAD3 RAD26 ACO1 MDH1
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] cofactor catabolism50.011.82e-01

564, 51e-01YDL239C BBP1 NIP29 YPL070W
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] microtubule organizing center organization and biogenesis50.014.31e-02
[C] cytoskeleton75.01.63e-02
[C] spindle75.03.95e-02
[C] microtubule organizing center50.03.58e-02
[C] immature spore25.06.79e-01

574, 51e-01CYC8 TUP1 RPD3 SIN3
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] regulation of biological process100.00.74e-02
[P] regulation of cellular metabolism100.01.15e-02
[P] regulation of metabolism100.01.06e-02
[P] regulation of cellular process100.00.77e-02
[P] regulation of cellular physiological process100.00.77e-02
[P] regulation of physiological process100.00.78e-02
[F] deacetylase activity50.012.59e-02
[F] general transcriptional repressor activity50.0100.02e-01
[P] regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism100.01.35e-01
[P] DNA metabolism100.00.96e-01

584, 51e-01GSP1 KAP95 RNA1 GSP2
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] nuclear organization and biogenesis50.04.36e-01

594, 51e-01YDR013W YJL072C YLR320W CTF4
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] GINS complex50.050.01e-03
[C] chromosome75.01.17e-02
[P] DNA metabolism100.00.92e-01
[C] nuclear chromosome75.01.35e-01

604, 51e-01YDR078C SHU1 YLR376C SHU1
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] error-free DNA repair100.075.02e-04
[P] response to stimulus100.00.64e-02
[P] DNA metabolism100.00.75e-01
[F] molecular function unknown100.00.27e-01
[P] DNA repair100.02.09e-01

615, 74e-01CDC53 GRR1 HRT1 CLN2 POR1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] ubiquitin ligase complex60.08.61e-03
[C] nuclear ubiquitin ligase complex60.013.01e-03
[F] ligase activity60.03.04e-02
[P] cell cycle80.01.18e-02
[P] SCF-dependent proteasomal ubiquitin-dependent protein catabolism60.042.93e-01
[P] protein catabolism60.02.14e-01
[P] macromolecule catabolism60.01.24e-01
[P] cellular protein catabolism60.02.24e-01
[P] ubiquitin cycle60.04.85e-01
[P] biopolymer catabolism60.01.46e-01

625, 74e-01SIP2 ARC15 ARC19 ARC18 ARC35
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] Arp2/3 protein complex80.057.12e-08
[P] organelle inheritance80.012.11e-04
[P] mitochondrion localization80.018.23e-04
[P] organelle localization80.08.29e-04
[C] cytoskeleton80.02.13e-03
[P] mitochondrion organization and biogenesis80.05.34e-03
[F] structural molecule activity80.01.65e-03
[P] cytoskeleton organization and biogenesis80.02.02e-01
[C] non-membrane-bound organelle80.00.54e-01
[C] intracellular non-membrane-bound organelle80.00.54e-01

635, 74e-01MSH5 RAD57 PGD1 MRE11 CST9
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] cell cycle80.01.16e-02
[C] Mre11 complex20.033.37e-01
[P] DNA recombination60.03.48e-01

645, 74e-01MRPL16 MRPL10 MRPL3 MRPL28 MRPL35
AnnotationSpecificity(%)Sensitivity(%)p-value
[F] structural molecule activity100.01.93e-05
[C] ribosome100.02.83e-05
[C] ribonucleoprotein complex100.01.53e-04
[C] mitochondrial lumen100.03.69e-04
[C] membrane-enclosed lumen100.00.82e-03
[C] organelle lumen100.00.81e-02
[P] macromolecule biosynthesis100.01.22e-02
[C] mitochondrion100.00.72e-02
[P] cellular biosynthesis100.00.84e-02
[C] non-membrane-bound organelle100.00.65e-02

655, 74e-01ZUO1 SCP160 ASC1 YAR014C KIN3
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] regulation of cellular metabolism80.01.17e-02
[P] regulation of metabolism80.01.08e-02
[P] regulation of biological process80.00.72e-01
[P] regulation of cellular process80.00.74e-01
[P] regulation of cellular physiological process80.00.74e-01
[P] regulation of physiological process80.00.74e-01
[C] ribonucleoprotein complex60.00.94e-01
[F] G-protein alpha-subunit binding20.0100.08e-01
[P] regulation of protein biosynthesis40.06.59e-01

665, 74e-01VPS32 VTA1 RIM20 VPS31 VPS4
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] endosome60.04.84e-03
[P] vacuolar transport80.06.63e-02
[P] endosome transport60.07.91e-01
[C] ESCRT III complex20.025.03e-01
[P] proteolysis60.01.96e-01
[P] cellular localization80.00.87e-01
[P] transport80.00.59e-01

675, 74e-01YBL049W YCL039W YDR255C FYV10 DCR1
AnnotationSpecificity(%)Sensitivity(%)p-value
[P] alcohol biosynthesis80.013.32e-04
[P] negative regulation of carbohydrate metabolism80.044.43e-04
[P] regulation of biosynthesis80.08.33e-04
[P] regulation of cellular biosynthesis80.08.34e-04
[P] regulation of carbohydrate metabolism80.014.34e-04
[P] negative regulation of gluconeogenesis80.044.45e-04
[P] alcohol metabolism80.02.96e-04
[P] carbohydrate metabolism80.02.32e-03
[P] generation of precursor metabolites and energy80.02.13e-03
[P] organic acid metabolism80.01.76e-03

685, 74e-01KAP104 SXM1 NUP100 NUP116 NUP1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] nuclear pore60.06.14e-03
[P] nuclear organization and biogenesis60.06.41e-02
[P] establishment of RNA localization80.05.62e-02
[P] nucleobase, nucleoside, nucleotide and nucleic acid transport80.05.33e-02
[C] nuclear envelope60.03.23e-02
[P] RNA localization80.04.94e-02
[P] nuclear transport100.04.95e-02
[P] transport100.00.65e-02
[P] nucleocytoplasmic transport100.04.76e-02
[P] localization100.00.66e-02

695, 74e-01SEC4 GDI1 21 YPT7 YIF1
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] cytoplasmic vesicle40.02.32e-01
[P] transport80.00.53e-01
[C] vesicle40.02.33e-01
[C] cytoplasmic membrane-bound vesicle40.02.33e-01
[P] localization80.00.53e-01
[C] organelle membrane60.00.73e-01

705, 74e-01PRP6 SPP381 SME1 LEA1 SMX3
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] small nuclear ribonucleoprotein complex100.07.82e-06
[C] ribonucleoprotein complex100.01.53e-04
[F] binding100.00.61e-02
[C] spliceosome complex60.04.13e-02
[F] RNA splicing factor activity, transesterification mechanism100.010.03e-02
[P] RNA metabolism100.01.25e-02
[C] protein complex100.00.49e-02
[P] mRNA processing100.03.93e-01
[P] RNA splicing100.04.33e-01
[P] mRNA metabolism100.02.86e-01

715, 74e-01PRP8 CLF1 RSE1 CUS1 HSH155
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] small nuclear ribonucleoprotein complex80.06.28e-05
[C] spliceosome complex80.05.41e-04
[P] spliceosome assembly80.023.58e-03
[F] binding100.00.62e-02
[C] ribonucleoprotein complex80.01.22e-02
[P] protein complex assembly80.03.12e-02
[P] RNA metabolism100.01.25e-02
[F] snRNA binding40.050.09e-02
[P] mRNA processing100.03.93e-01
[P] RNA splicing100.04.34e-01

725, 74e-01VPS5 VPS29 VPS35 PEP8 PEP8
AnnotationSpecificity(%)Sensitivity(%)p-value
[C] retromer complex100.080.01e-09
[C] endosome100.06.53e-06
[P] endosome transport100.010.56e-04
[F] transporter activity100.01.37e-04
[P] maintenance of localization75.017.69e-04
[P] maintenance of protein localization75.020.06e-03
[F] protein transporter activity100.07.83e-02
[C] membrane100.00.56e-02
[P] transport100.00.58e-02
[P] localization100.00.51e-01

735, 74e-01RPP1B RPP1A RPP2B RPL12B RPP0
AnnotationSpecificity(%)Sensitivity(%)p-value
[F] structural molecule activity100.01.93e-05
[C] ribosome100.02.83e-05
[C] cytosol100.02.22e-04
[C] ribonucleoprotein complex100.01.53e-04
[P] macromolecule biosynthesis100.01.22e-02
[P] translational elongation80.023.52e-02
[P] cellular biosynthesis100.00.84e-02
[C] non-membrane-bound organelle100.00.65e-02
[C] intracellular non-membrane-bound organelle100.00.65e-02
[P] biosynthesis100.00.76e-02